Li-GF le limolek'hule tsa bioactive tse teng ho PRP li khothalletsa liketso tse ka sehloohong tsa 4 tikolohong ea sebaka sa tsamaiso, tse kang ho ata, ho falla, ho arohana ha lisele, le angiogenesis.Li-cytokine tse fapaneng le li-GF li ameha taolong ea morphogenesis ea moriri le kholo ea moriri oa potoloho.
Lisele tsa dermal papilla (DP) li hlahisa li-GF tse kang IGF-1, FGF-7, hepatocyte growth factor, le vascular endothelial growth factor e ikarabellang bakeng sa ho boloka follicle ea moriri karolong ea anagen ea potoloho ea moriri.Ka hona, sepheo se ka bang teng e ka ba ho laola li-GF tsena ka har'a lisele tsa DP, tse lelefatsang karolo ea anagen.
Ho ea ka phuputso e entsoeng ke Akiyama et al, epidermal growth factor le transforming growth factor ke kenya letsoho ho laola khōlo le ho arohana ha lisele tse nang le li-bulge, 'me ntlha ea khōlo e entsoeng ke platelet e ka ba le mesebetsi e amanang le likamano pakeng tsa leqhubu le lisele tse amanang le tsona, ho qala ka follicle morphogenesis.
Ka thōko ho li-GF, karolo ea anagen e boetse e sebelisoa ke Wnt/β-catenin/T-cell factor lymphoid enhancer.Liseleng tsa DP, ts'ebetso ea Wnt e tla lebisa ho bokelleng ha β-catenin, eo, hammoho le T-cell factor lymphoid enhancer, e sebetsang hape e le motsoako oa ho ngola le ho khothalletsa ho ata, ho phela le angiogenesis.Lisele tsa DP joale li qala karohano 'me ka lebaka leo phetoho ea ho tloha telogen ho ea karolong ea anagen.Letšoao la β-Catenin le bohlokoa ho nts'etsopele ea follicle ea motho le bakeng sa potoloho ea kholo ea moriri.
Tsela e 'ngoe e hlahisitsoeng ho DP ke ts'ebetso ea "extracellular signal-regulated kinase" (ERK) le protheine kinase B (Akt) pontšo e khothalletsang ho phela ha lisele le ho thibela apoptosis.
Mokhoa o nepahetseng oo ka oona PRP e khothalletsang ho hōla ha moriri ha o utloisisoe ka botlalo.Ho hlahloba mekhoa e ka khonehang e amehang, Li et al, o ile a etsa thuto e entsoeng hantle ho batlisisa liphello tsa PRP ho hōla ha moriri ho sebelisa mefuta ea in vitro le ea vivo.Mohlala oa in vitro, PRP e sebelisitsoeng e ile ea sebelisoa ho lisele tsa DP tsa motho tse fumanoang letlalong le tloaelehileng la letlalo la motho.Liphello li bontšitse hore PRP e ekelitse ho ata ha lisele tsa DP tsa motho ka ho kenya tšebetsong pontšo ea ERK le Akt, e lebisang ho liphello tsa antiapoptotic.PRP e boetse e eketsa mosebetsi oa β-catenin le polelo ea FGF-7 liseleng tsa DP.Mabapi le mofuta oa in vivo, litoeba tse kentsoeng ka PRP e kentsoeng li bonts'itse phetoho e potlakileng ea telogen-to-anagen ha e bapisoa le sehlopha sa taolo.
Haufinyane tjena, Gupta le Carviel le bona ba ile ba etsa tlhahiso ea mokhoa oa ketso ea PRP ho follicles ea batho e kenyelletsang "ho hlahisa litsela tsa Wnt / β-catenin, ERK, le Akt tse matlafatsang ho phela ha lisele, ho ata le ho arohana."
Kamora hore GF e itlame le moqolotsi oa eona oa GF receptor, pontšo e hlokahalang bakeng sa polelo ea eona e qala.Moamoheli oa GF-GF o kenya tšebetsong polelo ea lipontšo tsa Akt le ERK.Ts'ebetso ea Akt e tla thibela litsela tsa 2 ka phosphorylation: (1) glycogen synthase kinase-3β e khothalletsang ho senyeha ha β-catenin, le (2) Bcl-2-e amanang le lefu le amanang le lefu, le ikarabellang bakeng sa ho susumetsa apoptosis.Joalokaha ho boletsoe ke bangoli, PRP e ka eketsa vascularization,thibela apoptosis, le ho lelefatsa nako ea karolo ea anagen.
Nako ea poso: Aug-24-2022