HA PRP Pokello Tube

Liphetoho tse ka sehloohong tsa pathophysiological tsa knee osteoarthritis ke tahlehelo ea lefufuru, subchondral bone reconstruction, osteophyte formation le synovial inflammatory reaction.Lipontšo tsa pele tsa kliniki ke ho ruruha, bohloko le ho satalla ha manonyeletso le lisele tse potolohileng.Ka tsoelo-pele ea lefu lena, butle-butle e lebisa ho se sebetseng ha manonyeletso 'me e ama ka botebo boleng ba bophelo.Ho ea ka phuputso eo, tekanyo ea lefats'e ea bokooa ba osteoarthritis e ne e le 2.2% ka 2010, 'me palo ea batho ba nang le bokooa selemong sona seo e ile ea feta limilione tse 1,7, e leng se ileng sa tlisa kotsi e tebileng sechabeng, malapa le batho ka bomong.HA ke biomaterial e phahameng ea molek'hule ea polysaccharide e entsoeng ka ho fapanyetsana khafetsa ha n-acetylglucuronic acid.Ke karolo e ka sehloohong ea motsoako oa motsoako oa synovial le e 'ngoe ea likarolo tsa matrix a lefufuru.E phetha karolo ea phepo e nepahetseng le tšireletso ea manonyeletso.HA ho phekoloa lefu la masapo a manonyeletso ho 'nile ha pakoa ka tleliniking hore e na le phello e itseng ho kokobetsa matšoao a bohloko ba lengole le ho ntlafatsa ho tsamaea ha lengole.Leha ho le joalo, ka lebaka la khaello ea tšehetso e thehiloeng bopaking, haholo-holo ts'ebetso e sa tsitsang ea nako e telele, tataiso ea morao-rao ea AAOS bakeng sa ho hlahlojoa le ho phekoloa ha lefu la masapo a mangole ha e khothalletse tšebeliso ea hyaluronic acid, 'me boemo ba khothaletso bo khothaletsoa ka matla.Triamcinolone acetonide, joalo ka glucocorticoid ea maiketsetso ea nako e telele, e na le phello e matla le e tšoarellang ea anti-inflammatory.

Mokhoa oa eona ke ho thibela phagocytosis le ho sebetsa ha li-antigen ka macrophages;Ho tsitsisa lera la lysosomal le ho fokotsa ho lokolloa ha hydrolase ho lysosome;Thibela ho falla ha leukocyte le macrophages ho tsoa methapong ea mali le ho fokotsa karabelo ea ho ruruha.Phuputso ena e fana ka maikutlo a hore phello ea ente ea intra-articular ea triamcinolone acetonide e ntle nakong ea khoeli ka mor'a phekolo, empa ka nako ea ho tlohela mosebetsi, haholo-holo ka mor'a likhoeli tse 6 tsa phekolo, phello e tlaase haholo ho lihlopha tse ling tse peli.Mcalindon le liphuputso tse ling li bontšitse hore ho bakuli ba nang le matšoao a nang le lefu la masapo a mangole, ente ea intraarticular ea triamcinolone acetonide e bakile tahlehelo e kholo ea molumo oa lefufuru 'me ha ho na phapang e khōlō mahlaba a mangole ha a bapisoa le saline e tloaelehileng.

Liphuputso tse ka holimo ha li tšehetse phekolo ena bakeng sa bakuli ba nang le matšoao a mangole a mangole.Bafuputsi ba bang ba sebelisitse triamcinolone acetonide le sodium hyaluronate intra-articular injection ho phekola osteoarthritis ea lengole, 'me katleho ea eona ea nako e khutšoanyane le ea nako e telele e molemo ho feta ea hyaluronic acid feela.E le phekolo e ncha, PRP e ka fumanoa ho tsoa maling a mokuli a autologous, ntle le ho lahloa ha 'mele oa ho itšireletsa mafung,' me e na le lintlha tse phahameng tsa ho hōla.Lintlha tsa ho hōla li 'nile tsa pakoa hore li khothalletsa ho ata ha chondrocyte le extracellular matrix synthesis.Ho feta moo, liphuputso tsa morao tjena li bontšitse hore PRP e ka thibela ho ruruha ha baktheria ea synovium ka tekanyo e itseng ha e ntse e khothalletsa ho tsosolosoa ha chondrocyte.Liteko tse ntseng li eketseha tsa liphoofolo le lithuto tsa bongaka li fana ka maikutlo a hore e sebetsa hantle.Phuputso ena e bontša hore palo ea PRP ea WOMAC ho 1 le likhoeli tsa 3 ka mor'a phekolo e lekana le ea hyaluronic acid, 'me palo ea PRP ea WOMAC likhoeling tsa 6 ka mor'a phekolo e molemo ho feta ea lihlopha tse ling tse peli, e fana ka maikutlo a hore e na le pheko e ntle ya nako e mahareng le e telele.Leha ho le joalo, ka lebaka la khaello ea thuto ea nako e telele ea kliniki ea lisampole tse kholo le ho hloka tšehetso e tobileng ho tsoa ho biology e eketsehileng ea limolek'hule kapa litšoantšo tsa MRI, lipatlisiso tse eketsehileng le puisano li ntse li hlokahala.